Effect of SERCA gene modified stem cells on functional recovery of diabetic cardiomyopathy /
جين على الانتعاش الوظيفى فى اعتلال عضلة القلب السكرى SERCA2a تأثير الخلايا الجذعية المعدلة بال
Yasmeen Safwat Salah Mohamed ; Supervised Lobna Abdelaal Kassem , Maha Mohamed Gamal Eldin , Nadia Aziz Yassin
- Cairo : Yasmeen Safwat Salah Mohamed , 2016
- 185 Leaves : charts , facsimiles , photographs ; 30cm
Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Molecular Physiology
Aims/hypothesis: This study addressed the potential application of genetically modified mesenchymal stem cells (MSCs) was sarcoplasmic reticulum Ca⁺² ATPase2a (SERCA2a) gene in the treatment of diabetic cardiomyopathy (DC) focusing on the role of (SERCA2a) in the pathogenesis of such dysfunction. Methods: 50 rats were divided into five groups: control, DC, DC treated with either MSCs or genetically modified MSCs (MSCs SERCA2a) injected in tail vein or MSCsSERCA2a and ascorbic acid A.A