TY - BOOK AU - Mohammad Mamdouh Abdelwareth AU - Carmen Villmann , AU - Hans-Georg Breitinger , AU - Ulrike Breitinger , TI - Molecular repair mechanisms-combined effects of gain-and loss-of- function mutants on channel function of the inhibitory glycine receptor / PY - 2014/// CY - Cairo : PB - Mohammad Mamdouh Abdelwareth , KW - Channel function KW - Glycine KW - Synapse N1 - Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Biotechnology N2 - Fast synaptic inhibitory neurotransmission in the central nervous system is principally mediated by {u01B4}-aminobutyric acid type A receptors(GABAAR) and glycine receptors(G1yR). The spinal cord and brainstem are main sites of actionof glycine receptors. Glycinergic synapses are present in spinal cord motor reflex pathways, spinal cord nociceptive ( pain sensory) pathawys ER -