TY - BOOK AU - Radwa Ayman Salah Helmy AU - Ahmed Ihab Abdelaziz , TI - Reduction of hepatitis C viral replication through targeting HCV-genotype 4p7 Ion channal by MicroRNA-29a / PY - 2013/// CY - Cairo : PB - Radwa Ayman Salah Helmy , KW - HCV-genotype 4p7 Ion channal KW - Hepatitis C virus infection (HCV) KW - MicroRNA-29a N1 - Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Molecular Pharmacology N2 - Hepatitis C virus infection (HCV) is a global health crisis, characterized by a virusmediated suppression of the host immune response. It is considered a leading cause of chronic liver disease worldwide. Egypt is considered to have the highest prevalence of HCV globally (17%), where the majority of cases are infected with the " difficutlt-to-treat" genotype 4.p7 is viral protein that acts as an ion channel and has a crucial role in HCV life cycle, rendering it an attractive therapeutic target ER -