Ahmed Mohamed Mohamed Abdellah <br/><br/>
Therapeutic effect of bone marrow derived mesenchymal stem cells in rats :   Experimental clinico-pathological and pathological study /  
 التأثير العلاجى للخلايا الجزعية الوسيطه المستخلصه من نخاع العظام على التليف الكبدى فى الفئران :   دراسة تجريبية باثولوجية إكلينيكية و باثولوجية 
Ahmed Mohamed Mohamed Abdellah ; Supervised Mohamed Ibrahim Dessouky , Nashwa Adel Abu-Aita , Hanaa Ahmed Amer 
 - Cairo :   Ahmed Mohamed Mohamed Abdellah ,   2016 
 - 163 P. :   charts , photographs ;   30cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology 
<br/><br/> Stem cells' therapy provides a novel therapeutic strategy for treatment of liver fibrosis and cirrhosis, and can be considered as an alternative to liver transplantation. The concept of the present study was to evaluate the therapeutic effect of bone marrow derived mesenchymal stem cells in carbon tetrachloride induced liver fibrosis in rats. S/C administration of carbon tetrachloride to Wistar rats for six weeks at a dose of 0.2 ml/100 gm body weight altered hematological and biochemical parameters. It induced significant leukocytosis, elevated the activities of hepatic enzymes (AST, ALT and ALP), increased serum bilirubin concentration and induced significant hypoproteinemia and hypoalbumemia. Moreover, it increased the percentage of fibrous tissue in liver parenchyma. Administration of bone marrow derived mesenchymal stem cells at a dose of 3106 cells per rat alleviated alterations in the previously mentioned hematological, biochemical and histopathological parameters. The obtained results suggested that bone marrow derived mesenchymal stem cells can be a potent cellular therapy for liver fibrosis 
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<br/><br/><label>Subjects--Index Terms: </label>Bone marrow derived mesenchymal stem cells Carbon tetrachloride Liver fibrosis