Salwa Mohamed Khedr  <br/><br/>
Human platelets antigen (HPA) polymorphism in Egyptian patients with immune thrombocytopenic purpura /  
 التعدد الجيني لمولدات مضادات الصفائح الدمويه البشرية في المرضي المصريين المصابيين بالنقص المناعي للصفائح الدمويه 
Salwa Mohamed Khedr ; Supervised Tayssir Kamel Eyada , Dalia Gamil Amin , Ihab Samih  
 - Cairo :   Salwa Mohamed Khedr ,   2016 
 - 230 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology  
<br/><br/> Background: Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder that affects both children and adults (Hoffbrand et al. 2016). It results from both accelerated destruction and sub-optimal production of platelets (Cines et al. 2009). Initial studies demonstrated a plasma-derived destructive effect, later identified as an anti-platelet antibody (Harrington et al. 1951). Anti- platelet antibodies are usually formed against the human platelet antigen (HPA)  system. The HPA systems are derived from the single base pair substitution in the encoding genes of platelet membrane glycoproteins (GP). The GP variants  resulting from amino acid substitutions are involved in the rate of  alloimmunization to platelet-specific antigens. Subsequently, the alloimmunization  can induce fetal and neonatal alloimmune thrombocytopenia (FNAIT) (Mueller- Eckhardt 1986), post-transfusion purpura (PTP), or platelet transfusion  refractoriness (PTR) (von dem Borne and Décary 1990). HPA systems are also  associated with organ transplantation rejection (Kekomäki et al. 2001) and cardiovascular disease (Ardissino et al. 1999) and are frequently assessed in general population studies. Therefore, accurate donor compatibility for platelet  transfusions is extremely important. 
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<br/><br/><label>Subjects--Index Terms: </label>HPA  polymorphisms  Human platelet antigens (HPA)  Immune thrombocytopenia