TY  - BOOK
AU  - Iman Hassan Ezzat Elkhashab
AU  - Amany Ibrahim Elbrairy , 
AU  - Amina Salem Attia , 
AU  - Rania Mohsen Abdelsalam , 
TI  - The possible protective potential of certain agents in global cerebral behemia-reperfusion induced in rats / 
PY  - 2016///
CY  - Cairo : 
PB  - Iman Hassan Ezzat Elkhashab , 
KW  - Chrysin
KW  - Cilostazol
KW  - Ischemia-reperfusion
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Background. Global cerebral Ischemia is one of the leading causes of mortality worldwide. The sudden cessation of blood flow to the brain initiates a cascade of events that leads to severe neuronal brain damage. Allowing reperfusion after ischemia causes further cerebral damage. The neuroprotective effect of cilostazol, a phosphodiesterase inhibitor III, and chrysin, a flavonoid, has not been investigated on global cerebral ischemia, thus it seemed interesting to investigate both drugs in ischemia-reperfusion (I/R) in rats.  Methods. Male Wistar rats weighing 200-250 were allocated into four groups. I. Sham-operated control group, II. I/R group subjected to global cerebral ischemia for 15 minutes followed by reperfusion for 60 minutes. Groups III and IV were treated with cilostazol (30 mg/kg p.o.) and chrysin (30 mg/kg p.o.), respectively, for 2 weeks followed by global I/R on the 15th day. Throughout the I/R procedure, rats were  subjected to anesthesia with thiopental 30 mg/kg, then they were sacrificed by decapitation. Both hippocampi were rapidly excised to determine the oxidative stress biomarkers: Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), NADPH oxidase activity and xanthine oxidase (XO) activity and the  inflammatory mediators: interleukin 10 (IL-10), interleukin (IL-6) and tumor necrosis factor alpha (TNF-Ü). Apoptotic factors: heat shock protein 90 (HSP 90), Ý-cell lymphoma 2 (BCL-2) and BCL-2 associated X protein (BAX), as well as the excitatory neurotransmitters: glutamate and aspartate, were also evaluated
UR  - http://172.23.153.220/th.pdf
ER  -