Abdalla Youssef Fawzy Mohamed  <br/><br/>
The Impact of biodegradable polymer drug eluting stents on the outcome of acute coronary syndrome /  
 تأثير الدعامات النشطة حيويا القابلة للتحلل على نتائج القسطرة التداخلية فى مرضى الأزمة القلبية الحادة  
Abdalla Youssef Fawzy Mohamed ; Supervised Ahmed Abdelaziz , Ayman Moharam , Ibrahem Atia 
 - Cairo :   Abdalla Youssef Fawzy Mohamed ,   2017 
 - 116 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine 
<br/><br/> The early benefit of early generation of drug eluting stent (DES) in terms of target  lesion revascularization compared to bare metal stents was offset by increased  incidence risk of late stent thrombosis. Newer generation biodegradable polymer DES was seen to improve vascular healing and clinical outcome. In this study we aim to assess of the role of biodegradable polymer DES in  decreasing the incidence of major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI) in comparison with durable polymer DES in patients with noníST-segment elevation acute coronary syndromes  (NSTEACS).  Methodology and Results  This is a prospective, randomized study to compare between biodegradable polymer DES and durable DES. A total of 121 patients presenting to Critical Care Medicine Department, Cairo University with (NSTE-ACS). Participants were followed up clinically after  1-2 years. 52 of the patients with 69 lesions were allocated to treatment with BP DES and 69 patients with 86 lesions to treatment with DP DES.  For overall incidence of in-hospital complications, comprising acute  myocardial infarction, need for target lesion revascularization, urgent deferral to CABG and death there was no significant difference among different stents, (P 0.328). Also there was no significant differences among different stents in their 1-2  year follow up; seven patients were reported in 2follow-up MACCE3. Mortality  was 1.7% (1 biodegradable DES & 1 durable polymer DES). (P 0.654) Five  patients needed TLR (2 biodegrabale DES & 3 durable polymer DES). (P 0.632)  Conclusions   Biodegradable polymer and durable polymer DES are associated with similar  clinical outcomes at 2 years.  
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<br/><br/><label>Subjects--Index Terms: </label>Acute coronary syndrome  Biodegradable polymer drug Drug eluting stent (DES)