TY  - BOOK
AU  - Lamiaa Mohamed Mahmoud Ibrahim 
AU  - Hend Ashour Ahmed , 
AU  - Nashwa Eltablawy , 
AU  - Samah Mohamed Elattar , 
TI  - Effect of melatonin and mesenchymal stem cells treatment on diabetic nephropathy in male rats / 
PY  - 2017///
CY  - Cairo : 
PB  - Lamiaa Mohamed Mahmoud Ibrahim , 
KW  - diabetic nphropathy
KW  - Melatonin
KW  - MSCs
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology; Issued also as CD
N2  - Background: Diabetes has become a widespread epidemic, including  the increasing prevalence and incidence of type 1 diabetes. Diabetic  nephropathy (DN) is a common complication of diabetes. In recent years,  mesenchymal stromal cells (MSCs) have been highlighted as a new  emerging regenerative therapy due to their multipotency, and paracrine  secretion of angiogenic factors, cytokines, and immunomodulatory  substances. MSCs may also have glucose lowering properties providing  another attractive and unique feature of this therapeutic approach. MSC  administration has significant potential in the treatment of DN but  challenges remain in terms of engraftment, persistence, and tissue  targeting. Melatonin seems to regulate signaling pathways that drive  differentiation of MSC into different tissues.  Objective: This study tried to evaluate the effects of melatonin or stem  cells (especially those attenuated with melatonin) on streptozotocin  induced DN in type 1 diabetic male rats.  Methods: sixty adult male albino rats were divided into: Control group  (I), diabetic group (II), diabetic + melatonin (III) group given melatonin  intraperitoneal for 2 weeks after induction of diabetes, diabetic + stem  cells (IV) group treated with stem cells a single dose by intravenous  injection in rat tail vein after induction of diabetes and diabetic + stem cells attenuated with melatonin (V) group treated with stem cells after  attenuation with melatonin ex vivo after induction of diabetes. At the end of the study period, GFR, BP, serum fasting blood glucose,  serum insulin, plasma and urine creatinine level, Urea, urinary albumin  excretion (UAE), serum angiotensin level, carboxymethyl lysine, kidney  tissue level of : (tumor necrosis factor-alpha (TNF-Ü), Interleukin10 (IL- 10), Basic fibroblast growth factor (b-FGF), Super oxide dismutase), and glomerular expression of (TGF-Ý, Bcl-2, Beclin) were measured
UR  - http://172.23.153.220/th.pdf
ER  -