TY  - BOOK
AU  - Heba Ibrahim Mohamed Abdallah
AU  - Aly Fahmy Mohamed, 
AU  - Mahmoud Mohamed Ghorab , 
TI  - Study the effect of nano and micro encapsulation of DNA vaccine model on its stability and immunogenicity / 
PY  - 2017///
CY  - Cairo : 
PB  - Heba Ibrahim Mohamed Abdallah , 
KW  - DNA
KW  - DNA vaccine model
KW  - Nano and micro encapsulation
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Herpes simplex virus type 2 (HSV-2) is a one of the most prevalent worldwide sexually transmitted infection. HSV-2 causes recurrent genital ulcers, neonatal herpes, and also, increases the risk for human immunodeficiency virus (HIV) acquisition. Many HSV-2 vaccines have been tested in humans, but were not consistently effective. In the present work we tried to produce a model vaccine for HSV-2 formulated in different formulae as an attempt for development of an effective prophylactic and therapeutic HSV-2 vaccine. Beta propiolactone (BPL) as a virus inactivant was compared with the conventional formalin (F). Gold and silver nanoparticles  were prepared with different concentrations as a vaccine adjuvants.  Also, calcium phosphate nanoparticles and bovine serum albumin nanoparticles were used as vaccine adjuvants . They were  compared with currently used aluminum phosphate gel (alum) microparticles
UR  - http://172.23.153.220/th.pdf
ER  -