Hebatalla Saad Teleb <br/><br/>
Effect of delta-aminolevulinic acid dehydratase polymorphism on susceptibility to lead poisoning among lead exposed workers /  
 تأثير تعدد الأشكال لحمض الدلتا أمينوليفولينك النازع للماء على القابلية للتسمم بالرصاص بين العمال المعرضين للرصاص 
Hebatalla Saad Teleb ; Supervised Mona Sobhy Siha , Lalia Ahmed Rashed , Dalia Abdelhamid Shaker 
 - Cairo :   Hebatalla Saad Teleb ,   2017 
 - 173 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Industrial Occupational and Environmental Medicine 
<br/><br/> Introduction:Lead is used in ammunition industry. It has been associated with several health hazards among exposed workers. Aim:The aim of this work isto obtain some insights of the distribution of e-ALAD polymorphism among lead exposed workers and their effect on some hematological and renal indices. Subjective and methods:This study was conducted on 50 lead exposed workers compared to 50 non-exposed individuals, where full history, clinical examination, and laboratory investigations in the form of: genetic study of e-ALAD gene polymorphism, blood leadlevel, CBC, serum creatinine and urea, U-e-aminolevulinic acid, U-B2-microglobulin were done. Results:Statistically significant (p<0.05) differences were found between exposed and control as regards the prevalence ofhematological, renal, GIT and neurological manifestations. Compared to the control group, urinary B2-microglobulin, urinary e-ALADH, serum urea, serum creatinine and blood lead levelwere significantly higher among exposed workers, while significantlylowerin the mean values of complete blood picture (RBCs, Hb, MCV, MCH, MCHC and PLT) 
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<br/><br/><label>Subjects--Index Terms: </label>Ammunition industry  Blood lead  e-ALAD Polymorphism