Ayat Gamal Ali Ahmed <br/><br/>
Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents /  
 إكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان 
Ayat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud 
 - Cairo :   Ayat Gamal Ali Ahmed ,   2017 
 - 175 P. :   charts , facsimiles , photographs ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry 
<br/><br/> In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway 
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<br/><br/><label>Subjects--Index Terms: </label>Adamantane thiadiazole derivatives Cytotoxicity Molecular modeling