TY  - BOOK
AU  - Ayat Gamal Ali Ahmed
AU  - Abdou Osman Abdelhamid , 
AU  - Magda Fikry Mahmoud , 
AU  - Mervat Elsayed Mohamed , 
TI  - Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / 
PY  - 2017///
CY  - Cairo : 
PB  - Ayat Gamal Ali Ahmed , 
KW  - Adamantane thiadiazole derivatives
KW  - Cytotoxicity
KW  - Molecular modeling
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway
UR  - http://172.23.153.220/th.pdf
ER  -