Mai Ibrahim Aboelmagd Ali <br/><br/>
Synthesis and anticonvulsant evaluation of certain moieties derived from diazaspiroalkanediones /  
 تشييد وتقييم الفاعلية المضادة للتشنجات لبعض الجزيئات المشتقة من ثنائي ازاسبيرو الكان داي اون  
Mai Ibrahim Aboelmagd Ali ; Supervised Mohamed Nabil Aboul-Enein , Kamilia Mahmoud Amin  
 - Cairo :   Mai Ibrahim Aboelmagd Ali ,   2017 
 - 147 P. ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry 
<br/><br/> This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6 
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<br/><br/><label>Subjects--Index Terms: </label>Anticonvulsant  Diazaspiroalkanediones  Molecular modeling