TY  - BOOK
AU  - Mai Ibrahim Aboelmagd Ali
AU  - Kamilia Mahmoud Amin , 
AU  - Mohamed Nabil Aboul-Enein , 
TI  - Synthesis and anticonvulsant evaluation of certain moieties derived from diazaspiroalkanediones / 
PY  - 2017///
CY  - Cairo : 
PB  - Mai Ibrahim Aboelmagd Ali , 
KW  - Anticonvulsant
KW  - Diazaspiroalkanediones
KW  - Molecular modeling
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6
ER  -