TY - BOOK AU - Fayroz Farouk Ibrahim Sherif AU - Abdalla Sayed Ahmed , AU - Manal Abdelwahed , AU - Yasser Mostafa Kadah , TI - Gene-gene interaction detection and disease progression models for alzheimer disease / PY - 2017/// CY - Cairo : PB - Fayroz Farouk Ibrahim Sherif , KW - Alzheimer disease KW - Bioinformatics KW - Gene-gene interactions N1 - Thesis (Ph.D.) - Cairo University - Faculty of Engineering - Department of Systems and Biomedical Engineering; Issued also as CD N2 - The discovery of genetic variants between two groups of healthy and diseased people contributes to the identification of genetic markers of Alzheimer's. We aim to find a new set of genetic changes strongly associated with Alzheimer's disease, and detecting the interactions between these variables (Epistasis interactions) using a new hybrid method combining statistical and biological methods based on (IHOEB). In addition, we have proposed a probability model through which early progression rates can be estimated and information on the level of disease severity and the time it takes to move to the next level can be expected ER -