TY  - BOOK
AU  - Khaled Ragab Abdelhakim
AU  - Mira Farouk Youssef , 
AU  - Noha Mohamed Afifi Amin , 
AU  - Soheir Assaad Filobbos , 
TI  - Possible protective effect of melatonin on cisplatin-induced testicular toxicity in adult albino rats : : A histological and immunohistochemical study / 
PY  - 2017///
CY  - Cairo : 
PB  - Khaled Ragab Abdelhakim , 
KW  - Cisplatin
KW  - Melatonin
KW  - Rat testis
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology; Issued also as CD
N2  - Chemotherapy may result in temporary or permanent gonadal toxicity in male patients. Loss of fertility potential can be devastating to patients, especially, during the child-bearing period. The present study was planned to investigate the possible protective effect of melatonin, in a rat model of cisplatin-induced testicular toxicity. Forty five adult male albino rats were divided into four groups; Group I Control (n=15) received 0.9% sodium chloride and/or distilled water as a vehicle. Group II (n=10) were injected intraperitoneally (I.P.) with a single dose 7 mg/kg of cisplatin & were sacrificed after 10 days. Group III (n=10) received melatonin daily orally at a dose of 8 mg/kg/day for 10 days. Group IV (n=10); oral melatonin administration started 5 days before the single I.P. injection of cisplatin, followed by continuation of melatonin for further 10 days. Testicular sections were subjected to H&E, immunohistochemical staining for anti-inducible nitric oxide synthase (iNOS) and anti-androgen receptor (AR). The study proved the protective effect of melatonin against testicular toxicity, when administered prior to and concomitant with cisplatin therapy; confirming the anti-oxidant potential of melatonin
UR  - http://172.23.153.220/th.pdf
ER  -