TY  - BOOK
AU  - Rana Magdy Mohamed Yehia
AU  - Amr Shafik Saad , 
AU  - Hanan Salah Eldin Elabhar , 
AU  - Samira Saleh Mostafa , 
TI  - The potential prophylactic effect of exogenous antioxidant 2L-carnosine3 on oxaliplatin-induced peripheral neuropathy in colorectal cancer patients / 
PY  - 2017///
CY  - Cairo : 
PB  - Rana Magdy Mohamed Yehia , 
KW  - L-carnosine
KW  - Oxaliplatin
KW  - TNF-Ü
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Background: Chemotherapy-induced peripheral neuropathy is a common side effect afflicting cancer patients treated with oxalipatin-based chemotherapy. Aim: The study investigated the potential prophylactic effect of L-carnosine against acute oxaliplatin neurotoxicity in colorectal cancer patients with emphasis on the redox (Nrf-2, MDA), inflammatory (NF-mB, TNF-Ü), and apoptotic (caspase-3) parameters. Methods: In this pilot study, 65 patients were recruited using a prospective randomized controlled study design and enrolled randomly into two arms; Arm A, 31 patients received FOLFOX-6 regimen (oxaliplatin, 5FU and leucovorin) and Arm B, 34 patients received FOLFOX-6 regimen and daily oral L-carnosine (500 mg) along the treatment period. Patients were followed up for three months, then both arms were analyzed for neuropathy incidence/grade and any additional toxicities according to NCI-CTC version 4. Results: The neuropathy grading evaluation of Arm B vs Arm A revealed that 17 patients (56.7%) vs 11 patients (35.5%) suffered grade 1, one patient (3.3%) vs 19 patients (61.3%) suffered grade 2, while 12 patients (40%) vs one patient (3.2%) were normal
UR  - http://172.23.153.220/th.pdf
ER  -