Marwa Mostafa Abdelrahman Ahmed <br/><br/>
Studies of infectious coryza vaccine /  
 دراسات على لقاح مرض زكام الطيور المعدي 
Marwa Mostafa Abdelrahman Ahmed ; Supervised Kamelia Mahmoud Osman , Osama Elsebaey Kamal 
 - Cairo :   Marwa Mostafa Abdelrahman Ahmed ,   2017 
 - 211 P. :   charts , facsimiles , photographs ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology 
<br/><br/> Four vaccines formula with different adjuvants (liquid paraffin oil (vaccine no.  1), MontanideTM ISA 71 (vaccine no. 2), MontanideTM ISA 201(vaccine no. 3)  and MontanideTM Gel01 (vaccine no. 4)) and four vaccines formula by using  Date palm (Phoenix dactylifera L) and Mentha piperita immunomodulators  included in liquid paraffin oil adjuvant infectious coryza vaccine only in ratio of  1mg or 2mg of each immunomodulators, these 8 vaccines were used in  vaccination of 8- 10 weeks old chickens and evaluated by using Microplate  agglutination test (MAT), ELISA and challenge test. It was cleared that,  vaccines no. 3, 4 and 2 yielded a maximum of significant (P < 0.05 ) higher and  faster rate of antibody titer estimated by MAT and ELISA with a higher  challenge protection percentage than vaccine no. 1. Evaluation of the humoral  immune response of chicken vaccinated with liquid paraffin oil adjuvanated  infectious coryza vaccine with 1 mg ( vaccine no. 5) and 2mg ( vaccine no. 6) of  Date palm and also with 1mg ( vaccine no. 7 ) and 2mg ( vaccine no. 8) of  Mentha piperta by using MAT, ELISA, cleared that antibody titer increase  significantly (P < 0.05 ) at relative rates against the three antigens (W, Modesto,  0222) of Av. paragallinarum reaching maximum rates at the 10th to 12th week  post immunization also the use of these immunomodulators give a higher  protection percentage than vaccine no. 1. The data also cleared that the antibody  titer was higher by using of 2mg of either Date palm or Mentha piperita included  in the vaccine than using of 1mg. The results obtained in this study concluded  that, the infectious coryza vaccine adjuvanted with either MontanideTM  ISA71VG, MontanideTM ISA 201VG or MontanideTM Gel 01 adjuvant yielded  immune response in chicken better than that adjuvanated with liquid paraffin oil.  Also using an immunomodulators as Date palm and Mentha piperita included in  liquid paraffin oil adjuvant infectious coryza vaccine can enhance immune  response of chicken against infectious coryza disease 
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<br/><br/><label>Subjects--Index Terms: </label>Chicken against infectious coryza disease Infectious coryza vaccine Microbiology