Mirna Victor Azmy Ayad <br/><br/>
Design , synthesis and biological evaluation of novel tamoxifen analogues /  
 تصميم وتشييد وتقييم بيولوجي لمشتقات تاموكسيفين جديدة  
Mirna Victor Azmy Ayad ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed  
 - Cairo :   Mirna Victor Azmy Ayad ,   2017 
 - 94 Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry  
<br/><br/> Tamoxifen is the first SERM discovered to treat metastatic breasr cancer. Tamoxifen is metabolized to give 4-hydroxytamoxifen and 4-hydroxy N-desmethy1 Tamoxifen (Endoxifen) giving higher binding to Estrogen Receptor (ER) and higher potency in berast cancer calls. CYP2D6 and CYP3A4 are responsible for metabolizing Tamoxifen  
<br/><br/><label>Subjects--Index Terms: </label>CYP2D6  SERM Tamoxifen