TY  - BOOK
AU  - Mirna Victor Azmy Ayad
AU  - Ashraf H. Abadi , 
AU  - Nermin Salah Ahmed  , 
TI  - Design , synthesis and biological evaluation of novel tamoxifen analogues / 
PY  - 2017///
CY  - Cairo : 
PB  - Mirna Victor Azmy Ayad , 
KW  - CYP2D6
KW  - SERM
KW  - Tamoxifen
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - Tamoxifen is the first SERM discovered to treat metastatic breasr cancer. Tamoxifen is metabolized to give 4-hydroxytamoxifen and 4-hydroxy N-desmethy1 Tamoxifen (Endoxifen) giving higher binding to Estrogen Receptor (ER) and higher potency in berast cancer calls. CYP2D6 and CYP3A4 are responsible for metabolizing Tamoxifen
UR  - http://172.23.153.220/th.pdf
ER  -