Liza Samir Samy Botros <br/><br/>
Novel strychnine dimers as bivalent ligands targeting glycine receptors /  
 متشابهات ستركنين ثنائية التركيب جديدة كمثبطات لمستقبلات الجلايسين 
Liza Samir Samy Botros ; Supervised Darius P. Zlotos 
 - Cairo :   Liza Samir Samy Botros ,   2017 
 - 128 Leaves :   charts ;   30cm  
<br/><br/>Thesis (M.Sc.) - German University - Postgraduate Studies and Scientific Research  - Department of Pharmaceutical Chemistry 
<br/><br/> Strychnine in the major alkaloid from the seeds of Strychnos nux-vomica and strychnos ignati. As a natural product, its structure has been optimized for strong interactions with biological macromolecules through evolutionary selection. Its most pronounced pharmacological action is an antagonistic activity at glycine receptors (GlyRs)