TY  - BOOK
AU  - Rahma Mostafa Mahmoud Mansour Elbagoury 
AU  - Ashraf H. Abadi , 
AU  - Nermin S. Ahmed , 
TI  - Design and synthesis of flexible triphenylethylenes and their evaluation as anticancer Agents / 
PY  - 2017///
CY  - Cairo : 
PB  - Rahma Mostafa Mahmoud Mansour Elbagoury , 
KW  - CYP2D6
KW  - Tamoxifen
KW  - Triphenylethylenes
N1  - Thesis (M.Sc.) - German University - Faculty of  Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry
N2  - Tamoxifen is considered the gold standard for first-line treatment of all stages of breast cancer. It can be considered a classic "pro-drug" requiring metabolic activation to elicit pharmaceutical activity . CYP2D6 is the rate {u2013} limiting enzyme catalyzing the conversion of tamoxifen into metabolites with significantly greater affinity for the ER and greater ability to inhibit cell proliferation
UR  - http://172.23.153.220/th.pdf
ER  -