TY  - BOOK
AU  - Ibrahim Ahmed Ibrahim Abdalgawad
AU  - Laila Ahmed Rashed , 
AU  - Mohamed Ahmed Thabet , 
AU  - Soheir Abdelfattah Abuelfadl , 
TI  - Significance of serum microrna-122 levels in non-alcoholic fatty liver disease among Egyptian patients / 
PY  - 2018///
CY  - Cairo : 
PB  - Ibrahim Ahmed Ibrahim Abdalgawad , 
KW  - MicroRNA-122
KW  - NAFLD
KW  - Ultra sonography
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine; Issued also as CD
N2  - Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition. MicroRNA-122 (miRNA-122) is the most abundant micro-RNA (miRNA) in the liver, and it regulates metabolic pathways, including cholesterol biosynthesis, fatty acid synthesis and oxidation. Aim of the work: In the present study we aim to examine the correlation between the serum miRNA-122 expression levels and the presence of NAFLD and to analyze the relationship between the expressions of the serum miRNA-122 and different grades of (steatosis and fibrosis) using (ultra sonography and fibroscan) in NAFLD patients.Subjects and methods: patients were divided according to ultrasonographic findings into three groups with different degrees of steatosis (40 mild, 40 moderate and 40 patients with severe steatosis) in addition to 60 Egyptian age and sex matched controls. All patients enrolled in the study were subjected to full history taking, thorough examination, laboratory investigations (serum miRNA-122 levels by real-time polymerase chain reaction (PCR), insulin, lipid profile, blood glucose, AST, ALT) and radiological investigation in the form of abdominal ultra sonography and fibroscan. Results: This study found a statistical significant increase in serum miRNA-122 levels in NAFLD patients with compared to controls, with lower levels in patients with mild steatosis than those with moderate and severe steatosis. Also miRNA-122 levels were inversely correlated with fibrosis degree. Also in this study serum miRNA-122 levels were strongly associated with liver enzymes (ALT, AST and GGT)
ER  -