Menna Alla Mohie Eldein Elsayed Sherif <br/><br/>
Effect of cyclin D1 on the prognosis of multiple myeloma in Egyptian patients /  
 على التطور الأكلينيكى فى المرضى المصريين المصابين بالورم النقوى المتعدد D1 تأثير السيكلين  
Menna Alla Mohie Eldein Elsayed Sherif ; Supervised Lalia Abdelrahman Hegazy , Osman Mohamed Mansour , Reham Ahmed Rashed 
 - Cairo :   Menna Alla Mohie Eldein Elsayed Sherif ,   2018 
 - 129 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Background: Multiple myeloma is a disseminated malignancy of monoclonal plasma cells, diagnosed by 10% clonal bone marrow plasma cells or a biopsy infiltrated by plasma cells along with one or more of the multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions). Aim of work: Correlating Cyclin D1 with the prognosis of the patients. Subjects, materials and methods: Bone marrow biopsy of 50 patients newly diagnosed as Multiple myeloma were examined by immunohistochemistry for Cyclin D1, then these patients were followed up for a year. Results: There was significant correlation between Cyclin D1 and response of the patients. Conclusion: Cyclin D1 positive patients were found more likely to have worse prognosis than the negative ones  
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Cyclin D1  Immunohistochemistry  Multiple Myeloma