TY  - BOOK
AU  - Hend Abdelmotaleb Abdelrahman
AU  - Magdy Ibrahim , 
AU  - Mahmoud Eltawoosy , 
TI  - Design and preclinical evaluation of some bone seeking radiopharmaceuticals for medical application / 
PY  - 2018///
CY  - Cairo : 
PB  - Hend Abdelmotaleb Abdelrahman , 
KW  - Tc-99m
KW  - Tiludronate
KW  - Zoledronate
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - The aim of this study in its first chapter includes studying the factors affecting the labeling of tiludronate with Tc-99m, using direct labeling technique, and determination of the radiochemical purity of the labeled compound. The second chapter includes formulation of a novel bone imaging probe via Synthesis of a new organic ligand (EMIHPBP) with expected higher selective bone targeting, characterize the synthesized compound using IR, elemental analysis, mass spectroscopy and 1H-NMR, radiolabeling of the newly synthesized EMIHPBP with the radioactive technetium-99m, study factors affecting the labeling yield in details , evaluate its utility as a novel bone scintigraphy radiopharmaceutical agent via studying its biological distribution, finally tracing pharmacokinetics of 99mTc-EMIHPBP complex into bone was also been studied. Tiludronate and EMIHPBP were labeled with Tc-99m and gave maximum labeling yield of 93 and 91.51% ,respectively, at 200 and 1000?g of tiludronate and EMIHPBP, 2 and 50mg of NaBH4, reaction time of 30, and 60 min, respectively, at pH 10and 9 at room temperature. 125I-sibutramine, 125I-99mTc-EMIHPBP and 99mTc-tiludronate were stable up to 6h in-vitro and their uptake in bone was 31.6 and 29.74% injected activity/gm tissue organ at 60 and 300 min post-injection, respectively, and so they can be used as new radiopharmaceuticals for bone imaging
UR  - http://172.23.153.220/th.pdf
ER  -