Phenotypic screening of polymyxin resistance in commonly isolated extensively drug resistant gram negative bacteria in Cairo university hospitals /
بحث مقاومة البوليميجزين للبكتريا سالبة الجرام الاكثر شيوعا متعددة المقاومة للمضادات الحيوية فى مستشفى جامعة القاهرة
Raghdaa Tharwat Elmahdy ; Supervised Afaf Mohamed Samy Elbannah , Mona Mohiedeen Abdelhaleem , Reem Mostafa Mohamed
- Cairo : Raghdaa Tharwat Elmahdy Abdellatif , 2018
- 150 P. : facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
The polymyxin antibiotics are increasingly used as a last-line option for the treatment of infections caused by extensively drug-resistant Gram-negative bacteria. The aim of our study was to determine the prevalence of polymixin resistance among XDR gram negative isolates from Kasr Alainy Hospital. We collected 300 isolates of XDR acinetobacter spp., klebsiella pneumoniae and pseudomonas aeruginosa. Most of our isolates came from patients admitted to intensive care units (ICU), in 68.0% of XDR Klebsiella pneumoniae, 65.1% of Pseudomonas aeruginosa and 75.6% of acinetobacter baumannii isolates. The prevalence of colistin non-susceptibility among Klebsiella pneumoniae was 9%, in P. aeruginosa was 18% and in A. baumannii was 23%. To conclude, threats of XDR Klebsiella pneumoniae, pseudomonas aeruginosa and Acinetobacter baumannii isolates resistant to polymixins, become of a major concern in our hospital urging the implementation of infection control strategies and antimicrobial stewardship