TY  - BOOK
AU  - Eman Ahmed Youssef 
AU  - Hala Gabr, 
AU  - Nirmeen Adel , 
AU  - Reham Afeefy , 
TI  - Assessment of the role of NOGO gene block in enhancing the neuro-regenerative effect of mesenchymal stem cells / 
PY  - 2018///
CY  - Cairo : 
PB  - Eman Ahmed Youssef , 
KW  - Amyotrophic Lateral Sclerosis (ALS)
KW  - Mesenchymal stem cells (MSCs)
KW  - Neuroregeneration
N1  - Thesis (Ph.D.) - Cairo University -  Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Aim: Amyotrophic Lateral Sclerosis (ALS) is a fatal disease. Mesenchymal stem cells (MSCs) have a therapeutic potential in neuronal diseases, factors as NOGO A limit the axonal regeneration. In this study, gene silencing was used to suppress Nogo-A expression in MSCs, augmenting their neuro-regenerative role. Methods: MSCs were cultured from mice bone marrow then transfected with a plasmid coding for NOGO-A gene SiRNA, mouse models of motor neuron degeneration were created, therapeutic role of non-modified and plasmid transfected MSCs were studied and assessed clinically and histologically. Group 1 mice received no treatment. Group 2 received an IV injection of non modified MSCs and sacrificed 8 days (subgroup 2a) and 15 days (subgroup 2b) following treatment, Group 3 received an IV injection of transfected MSCs and were sacrificed 8 days (subgroup 3a) and 15 days (subgroup 3b) following treatment
UR  - http://172.23.153.220/th.pdf
ER  -