TY  - BOOK
AU  - Mennat Allah Mohammed Mahmoud Elsawah
AU  - Kamilia Mahmoud Amin , 
AU  - Walaa Ramadan Mahmoud , 
AU  - Yassin Mohammed Nissan , 
TI  - Synthesis and biological evaluation of some novel coumarin derivatives of expected cholinesterase inhibitory activity / 
PY  - 2018///
CY  - Cairo : 
PB  - Mennat Allah Mohammed Mahmoud Elsawah , 
KW  - Acetylcholinesterase
KW  - Alzehimer{u2019}s
KW  - Coumarin
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - Coumarin is an interesting bioactive scaffold eliciting a wide range of biological activities including anticancer, antibacterial, anti-inflammatory, antihypertensive and anticonvulsant activity. Herein, we highlighted on the acetylcholinesterase inhibitory activity of the coumarin nucleus notably 6-aminocoumarin derivatives which were reported to possess acetylcholinesterase inhibitory activity and many of them are in clinical trials. In this work, six series of 6-aminocoumarin-based compounds were synthesized. The target compounds featured a variety of bioactive chemical fragments of CNS action. Acetylcholinesterase inhibitory activity study was performed for all synthesized compounds. Furthermore, in silico studies were performed on the synthesized compounds which included molecular docking study at the active site of AChE enzyme as well as prediction of their pharmacokinetic parameters
ER  -