TY  - BOOK
AU  - Sama Magdy Farrag 
AU  - Ezz Eldeen Saeed Eldenshary , 
AU  - Mohamed Abdallah Hamzawy , 
AU  - Noha Nagah Nassar , 
TI  - Possible protective effects of nano-coenzyme Q10 and nano-vitamin E against atorvastatin-induced myopathy in hyperlipidemic rats / 
PY  - 2018///
CY  - Cairo : 
PB  - Sama Magdy Farrag , 
KW  - Atrovastatin
KW  - Co Q10
KW  - Nanoparticulate
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Statins are the most widely used to lower elevated low-density lipoprotein levels  and preventing cardiovascular diseases in humans. However, about 20% of patients  treated with this medication suffer from statin-related myalgia. To this end, this  study investigated the potential effect of nano-particulate formulation in alleviating  the muscles and liver damage either alone or when co-administered with nano  coenzyme Q10 (CoQ10) and nano vitamin E. Male Wistar rats were fed normal  diet or high-fat diet for 12 weeks, following which rats were treated with either (i)  atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10  mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or  nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH),  triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine  (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine  kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and  antioxidants 2reduced glutathione (GSH) and superoxide dismutase (SOD)3 were  measured. Additionally quadriceps muscles and liver tissues were used for  histopathological examination
UR  - http://172.23.153.220/th.pdf
ER  -