Role of activated platelet rich plasma in accelerating the healing rate of non-ischemic diabetic foot ulcer /
دور البلازما الغنية بالصفائح الدموية المنشطة فى تعجيل معدل التئام قرح القدم السكرى بعد اعادة التروية للاطراف
Ahmed Zaky Elsayed ; Supervised Hussein Mahmoud Khairy , Waleed Eldaly , Hossam Elmahdy
- Cairo : Ahmed Zaky Elsayed , 2018
- 72 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of General Surgery
Objective: To report data on the feasibility, safety, and effectiveness of activated platelet rich plasma in accelerating the healing rate of non-ischemic DFU. Design: This is a single center, prospective, randomized, controlled, blinded study that will be conducted in Cairo university, vascular surgery unit. Methods: 80 patients with non-ischemic DFU were classified into two groups: Group A: Patients with non-ischemic DFU and were treated with a novel modality i.e.: PRP injection in the healing edge and the floor of the targeted ulcer. Group B: Patients with non-ischemic DFU who had usual standard care i.e.: Moist dressing with or without collagenase ointment. All cases had a minimal debridement prior to treatment. Here, in our study the demographic data i.e. Age, sex, DM, HTN were homogenously distributed among both groups. All cases in both groups were non ischemic after successful revascularization either by OR or ER. Results: The rate of complete healing for ulcers in group A was achieved in 18 patients (45%) at the fifth week, while 20 patients (50%) were healed completely by the sixth week and only two patients (5%) healed in the ninth week. 27.8 %(n=10) cases in group B showed complete healing rate by eighth week and 50% (n=18 cases) were healed by ninth week while 22.2% (n=8) cases were healed in the tenth week. P value was statistically significant 0.001 between the groups