TY  - BOOK
AU  - Heba Nasr Mohamed Moustafa
AU  - Dalia Moustafa Eltanboul , 
AU  - Hala Fahmy Zaki , 
TI  - Neuroprotective evaluation of certain antiepileptic drugs on 3-nitropropionic acid-induced neurotoxicity in rat / 
PY  - 2018///
CY  - Cairo : 
PB  - Heba Nasr Mohamed Moustafa , 
KW  - AMPA
KW  - GluR2
KW  - Glutamate
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Prevalence of glutamate receptor subunit 2 (GluR2)-lacking Ü-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is a hallmark of excitotoxicity-related neurodegenerative diseases. Topiramate (TOP) is a structurally novel anticonvulsant with a well-known modulatory effect on AMPA/kainate subtypes of glutamate receptors. Levetiracetam (LEV) is a unique anti-epileptic acting mainly via inhibition of glutamate release. The present study aimed at investigating the neuroprotective potentials of TOP and LEV on 3-nitropropionic acid (3-NP)-induced striatal neurodegeneration and Huntington's disease (HD)-like symptoms. Rats were injected with 3-NP (10 mg/kg/i.p.) for 14 days, TOP (50 mg/kg/p.o.) and LEV (100mg/ kg/p.o.)  were given once a day, 1 h before 3-NP. Administration of TOP and LEV amended 3-NP induced changes in neurobehavioral performance, striatal neurotransmitters levels and histopathological injury. 3-NP control rats showed a significant ablation in the mRNA expression of Ca2+-impermeable Glu2R subunit along with an elevation in its regulatory protein PICK1, an effect that was largely reversed by TOP and LEV
UR  - http://172.23.153.220/th.pdf
ER  -