Samar Samy Mohamed Elsawy <br/><br/>
Efficacy and safety of paracetamol in the treatment of patent ductus arteriosus in preterm neonates :   A comparative study with indomethacin /  
 فعالية الباراسيتامول وأمان استخدامه في علاج القناة الشريانية المفتوحة عند الأطفال المبتسرين :   دراسة مقارنة بدواء الإندوميثاسين 
Samar Samy Mohamed Elsawy ; Supervised Aiman Saad Elkhatib , Mona Osman Abdelhalim , Hanan Zekri  
 - Cairo :   Samar Samy Mohamed Elsawy ,   2018 
 - 102 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> Background: High-dose paracetamol (60 mg/kg/day) has been shown equally effective to indomethacin for treatment of patent ductus arteriosus (PDA) in preterm infants but with added risk of liver toxicity. In few studies, however, paracetamol in lower doses has been suggested as a safer alternative without any reduction in efficacy. A recent hypothesis, which revealed that the initial constriction of the blood vessel of DA alone is insufficient to completely eliminate blood flow within the lumen of the ductus, stated that platelet aggregation is needed for permanent closure. Aim: To assess the effectiveness and safety of low dose paracetamol versus indomethacin for the treatment of PDA in preterm infants and to identify the association between the efficacy of either of the two drugs in PDA closure and the platelet counts  
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<br/><br/><label>Subjects--Index Terms: </label>Indomethacin  Paracetamol  Patent ductus arteriosus