TY  - BOOK
AU  - Sara Ibrahim Falah
AU  - Huda Marzouk Mohamed , 
AU  - Samia Salah Eldeen Mahmoud , 
AU  - Yomna Mohamed Farag , 
TI  - Evaluating galectin-3 (LGALS3) +191 gene variant and serum galectin-3 levels in Egyptian children with familial mediterranean fever / 
PY  - 2018///
CY  - Cairo : 
PB  - Sara Ibrahim Falah , 
KW  - FMF
KW  - Galectin-3
KW  - Proteinuria
N1  - Thesis (Ph.D.) - Cairo University -  Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background:The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Galectin-3 is a Ý-galactoside-binding lectin, which regulate cell-cell and extracellular interactions during self /non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis.It plays a significant role in the inflammatory response, the immune response and tissue fibrosis. The aim of the study isto evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of Albumin / Creatinine Ratio (ACR)
UR  - http://172.23.153.220/th.pdf
ER  -