Lamyaa Hany Abdellatif Soliman <br/><br/>
Role of apelin in the pathophysiology of esophageal varices complicating chronic HCV infection in Egyptian patients /  
 دور الابلين في الفيسيولوجية المرضية لدوالي المريء في مرضى الالتهاب الكبدي الوبائي سي المصريين 
Lamyaa Hany Abdellatif Soliman ; Supervised Iman Refaat Elmahgoub , Rania Ahmed Zayed , Fadwa Saied Abdelazim 
 - Cairo :   Lamyaa Hany Abdellatif Soliman ,   2018 
 - 150 P. :   charts ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Introduction and aim of work: Portal hypertension and esophageal varices formation complicating chronic HCV infection are considered the most devastating side effects of chronic liver disease owing to the bleeding-related mortality. Angiogenesis is the hallmark of their pathogenesis.  Apelin is one of the recently identified angiogenic and fibrogenic peptide of wide distribution in various tissues. We studied apelin gene expression and SNP (rs3761581) of the apelin gene in chronic HCV patients to assess their association with the degree of hepatic fibrosis, esophageal varices formation as well as the grade of esophageal varices 
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<br/><br/><label>Subjects--Index Terms: </label>aAngiogenesis  Apelin  Hepatitis C