TY  - BOOK
AU  - Emad Abdullah Deeb
AU  - Nadia Hanafy Metwally , 
TI  - Synthesis of some new pyrazoles and  their fused derivatives as antitumor agents / 
PY  - 2018///
CY  - Cairo : 
PB  - Emad Abdullah Deeb , 
KW  - 3-Aminopyrazolo [4,3-c]-pyridine-4,6-dione
KW  - 3-Cyanomethyl-4-cyano-5-amino-1H-pyrazole
KW  - Pyrazolo[4,3-c]pyridines
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry; Issued also as CD
N2  - The original work of this thesis includes:  The key intermediate 3-aminopyrazolo[4,3-c]pyridine-4,6-dione (2) is considered as  a precursor for some novel pyrazolo[4,3-c]pyridines such as 5a-c, 6a-c,  arylhydrazopyrazolo[4,3-c]-pyridines 8a-e pyrazolo[4,5,1-ij][1,6] naphthyridines  11a-e, 18a-d and pyrido[4',3':3,4]pyrazolo[1,5-a]-pyrimidines 15a-d, 19a-p through  Knovenegal condensation, coupling reaction and Michael addition. The structures  were confirmed by elemental analyses, spectral data and all possible have been  postulated to account for their formation. Some of the newly synthesized  pyrazolo[4,3-c]pyridine derivatives were investigated for anticancer activity. The  results of the cytotoxic activity revealed that compound 6b was the most active  compound against the breast and liver carcinoma cell lines which gives IC50 values  of 1.937 and 3.695 æg/mL, respectively compared to reference drug (doxorubicin)  with IC50 values of 2.527 and 4.749 æg/ml, respectively
ER  -