TY  - GEN
AU  - Manal Farouk Ahmed Abdelhafiz
AU  - Aisha Mostafa Abdelrahaman , 
AU  - Hoda Mohamed Abdelghani , 
TI  - Role and significance of DNA methylation in normal and abnormal hematopoiesis / 
PY  - 2006///
CY  - Cairo : 
PB  - Manal Farouk Ahmed Abdelhafiz , 
KW  - CpG islands
KW  - DNA methylation
KW  - Epigenetics in hematological malignancies
KW  - Hypermethylation
KW  - Hypomethylation
N1  - Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology; Issued also as CD
N2  - Data suggested that cancer appears to be a process that is fuelled both by genetic alterations and by epigenetic mechanisms Epigenetics refer to the study of changes in gene expression that can be mitotically inherited , but is not associated with the changes in the coding sequence of the affected genes The DNA methylation in the promoter regions is a powerful epigenetic mechanism for the suppression of gene activity Hypomethylation and hypermethylation are the two kinds of methylation defect that is observed in a wide variety of malignancies Hypomethylation is common in solid tumors such as metastatic hepatocellular cancer , in cervical cancer , prostate tumors , and also in hematological malignancies such as B - cell chronic lymphocytic leukemia A large number of genes involving fundamental cellular pathways may be affected by aberrant CpG island methylation in association with transcriptional silencing in virtually all tumor types
UR  - http://172.23.153.220/th.pdf
ER  -