Ola Mohammad Abdullah Elsaid Othman <br/><br/>
Micro RNA 192 as a new biomarker in the diagnosis of HCC /  
 استخدام حمض الريبونيكليك متناهي الصغر 192 كدلالة تشخيصية جديدة في مرضى سرطان الكبد 
Ola Mohammad Abdullah Elsaid Othman ; Supervised Abeer Mohamed Mohy Eldeen Elsaid , Hadeel Mohammad Elhanafi , Reham Aly Abbas Elshimy 
 - Cairo :   Ola Mohammad Abdullah Elsaid Othman ,   2019 
 - 114 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Background& Objective:Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. MicroRNAs regulate at least 60% of human genes, including tumour suppressor genes and oncogenes and, thereby, can affect cancer risk.MiRNA-192 is thought to be positive regulator of p53, a human tumor suppressor. They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets. It has also been suggested that miR-192 could be used as a biomarker for drug-induced liver damage. Aim of the work: In the present study, miRNA-192 expression levels (thought to be positive regulator of p53)in human HCC serum is intended to be examined by specific qRT-PCR to detect its role in HCC. Subjects &Methods:Fiftytwo newly diagnosed HCC cases and 30 apparently healthy individuals were recruited in this study. MiRNA-192 level was measured by TaqMan- Real time PCR assay 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Hepatocellular carcinoma (HCC) MiRNA-192  Real time PCR