TY  - BOOK
AU  - Ola Mohammad Abdullah Elsaid Othman
AU  - Abeer Mohamed Mohy Eldeen Elsaid , 
AU  - Hadeel Mohammad Elhanafi , 
AU  - Reham Aly Abbas Elshimy , 
TI  - Micro RNA 192 as a new biomarker in the diagnosis of HCC / 
PY  - 2019///
CY  - Cairo : 
PB  - Ola Mohammad Abdullah Elsaid Othman , 
KW  - Hepatocellular carcinoma (HCC)
KW  - MiRNA-192
KW  - Real time PCR
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Background& Objective:Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. MicroRNAs regulate at least 60% of human genes, including tumour suppressor genes and oncogenes and, thereby, can affect cancer risk.MiRNA-192 is thought to be positive regulator of p53, a human tumor suppressor. They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets. It has also been suggested that miR-192 could be used as a biomarker for drug-induced liver damage. Aim of the work: In the present study, miRNA-192 expression levels (thought to be positive regulator of p53)in human HCC serum is intended to be examined by specific qRT-PCR to detect its role in HCC. Subjects &Methods:Fiftytwo newly diagnosed HCC cases and 30 apparently healthy individuals were recruited in this study. MiRNA-192 level was measured by TaqMan- Real time PCR assay
UR  - http://172.23.153.220/th.pdf
ER  -