TY  - BOOK
AU  - Asmaa Ahmed Ibrahim Elmonier
AU  - Amira Abdelmonem Shaheen , 
AU  - Noha Ahmed Elboghdady , 
TI  - Genetic analysis of endoglin pathway components and their possible association with risk of preeclampsia in Egyptian women / 
PY  - 2019///
CY  - Cairo : 
PB  - Asmaa Ahmed Ibrahim Elmonier , 
KW  - Endoglin
KW  - Polymorphism
KW  - Preeclampsia
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry; Issued also as CD
N2  - Introduction:Preeclampsia(PE)isapregnancy-specifichypertensivediseasewhose etiopathogenesis remains unclear. Objectives: This study was designed to assess association between PE and 3 single nucleotide polymorphisms (SNPs): ENG (G/A) rs11792480, TGFÝR1 (A/C) rs10739778 and TGFÝR2 (G/A) rs6550005, beside the circulating level of soluble endoglin (sENG), oxidative stress biomarkers and nitric oxide (NO) in Egyptian women. Methods: The study included 75 preeclamptic women stratified into 4 clinical subgroups and 50 normotensive pregnant women. Genotyping was performed by real time polymerase chain reaction-TaqMan allelic discrimination. Results: Preeclamptic women showed significantly increased sENG and malondialdehyde (MDA) levels, decreased total antioxidant capacity (TAC), endothelial nitric oxide synthase (eNOS) and NO levels, without change in transforming growth factor beta 1 (TGFÝ1) level versus controls. Moreover, sENG was significantly higher in severe than mild PE and in early- than late-onset PE. Higher MDA and lower TAC and NO levels were observed in severe than mild PE. ENG (G/A) and TGFÝR2 (G/A) showed no association with PE. However, CC genotype of TGFÝR1 (A/C) was more frequent in controls than either PE, early-onset or severe PE revealing a reduced PE risk in CC genotype versus AA or AA+AC. Importantly, patients carrying AA genotype had higher systolic blood pressure (SBP) and MDA with lower TAC level, gestational age (GA) at delivery and birth weight than those carrying CC genotype
UR  - http://172.23.153.220/th.pdf
ER  -