TY  - BOOK
AU  - Hend Abdelhady Nooh Mahmood
AU  - Fatma A. Elrefaey , 
AU  - Ragia H. Badawy , 
AU  - Yasser  H. Elnahhas , 
TI  - Detection of IDH1 and IDH2 mutations in denovo acute myeloid leukemia patients at National Cancer Institute, Cairo University / 
PY  - 2019///
CY  - Cairo : 
PB  - Hend Abdelhady Nooh Mahmood , 
KW  - AML (Acute Myeloid Leukemia)
KW  - IDH (Isociterate Dehydrogenase)
KW  - Karyotype
N1  - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology; Issued also as CD
N2  - Introduction: AML is characterized by the uncontrolled clonal proliferation of poorly differentiated cells of myeloblasts. Isocitrate dehydrogenases (IDH1&2) are enzymes involved in multiple  metabolic and epigenetic cellular processes. Mutations in IDH1 or IDH2 induce production of an oncometabolite, 2-hydroxyglutarate (R-2-HG) which leads to DNA hypermethylation, and abnormal differentiation. IDH mutations diversely affect prognosis of patients with AML based on the presence of other co-occurring genomic abnormalities.  Aim of the work : The aim of this study was to assess the frequency of  IDH1& IDH2 genes mutations in AML patients and evaluate their role in disease prognosis.  Patients and Methods: We analyzed IDH mutations in 70 denovo AML patients (exon 4 for IDH1& exon 4 for IDH2) using High Resolution Melting (HRM) curve analysis
UR  - http://172.23.153.220/th.pdf
ER  -