Possible association between heme oxygenase-1 (HO-1) polymorphism and level of reactive oxygen species (ROS), in Egyptian type 2 diabetic patients /
امكانية الاقتران بين تعدد الشكل الجينى لهيم اوكسيجيناز 1 ومستوى انواع الاكسجين التفاعلية فى المصريين مرضى السكرى النوع الثانى
Maha Gomaa Sayed Ahmed ; Supervised Dina Sabry Abdelfatah , Miriam Safwat Wadie , Randa Fayez Salama
- Cairo : Maha Gomaa Sayed Ahmed , 2019
- 128 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry
Diabetes is a fast-growing health problem in Egypt with a significant impact onmorbidity, mortality, and health care resources. Currently, the prevalence of type-2 diabetes (T2D) in Egypt is around 15.6% of all adults aged 20 to 79. Oxidative stress (OS) has been suggested to be an important mechanism in the development of T2D complications. In the antioxidative system, heme oxygenase-1 (HO-1) acts as a key factor in mechanisms to mitigate oxidative stress because of its potent antiinflammatory, antioxidant, and antiproliferative actions. In addition, impaired HO-1 protein expression/activity may be related to the pathogenic process induced by OS. HO-1 gene promoter polymorphisms modulate its transcription in response to oxidative stress.This study screened for HO-1 polymorphisms and investigated the association between HO-1 polymorphisms and ROS levels in the serumin Egyptian diabetic population in comparison to control group. This study includes 3 groups: one hundred healthy subjects (control group), one hundred type diabetic (T1D) patients and one hundred and fourteen T2D patients