TY  - BOOK
AU  - Doaa Mohamed Abdelmoniem Hassan
AU  - Ismail Abdelshafy Abdelhamid , 
AU  - Said Ahmed Soliman Ghozlan , 
TI  - Utility of active methylene reagents as precursors for synthesis of New heterocycles / 
PY  - 2018///
CY  - Cairo : 
PB  - Doaa Mohamed Abdelmoniem Hassan , 
KW  - 3-amino-5-cyanomethypyrazole-4-carbonitrile
KW  - Bis-arylidenemalononitrile
KW  - Michael addition
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry; Issued also as CD
N2  - The thesis is composed of three main original parts. In part I, novel pyrazolo[l,5- a]pyridine derivatives containing (3-oxocyclohex-1-enyl)amino group at position 2 were synthesized in good yields using simple and efficient methodology. In part II, an efficient synthesis of novel bis-pyrazolo[l,5-a]pyridine derivatives through Michael addition reaction of 3-amino-5-cyanomethylpyrazole-4-carbonitrile with bis-arylidenemalononitrile is reported. In part III, a concise and efficient approach to tetrakis(uracil) derivatives by the reaction of bis(aldehydes) with four equivalents of 6-aminouracil is reported. Also, the synthesis of bis(pyrimido[4,5-b]quinolones) and bis(indeno[2',1':5,6]pyrido[2,3-d]pyrimidine) derivatives has been accomplished by a three-component reaction involving bis(aldehydes), 6-aminouracil and the appropriate cyclic-1,3-dione. The method involves domino Knoevenagel condensation/Michael addition reaction. All new compounds are characterized by different spectral tools
ER  -