TY  - BOOK
AU  - Tareq Hassan Muhmmad Jorob
AU  - Abdelbary Mohamed Prince , 
AU  - Motawa Essa Elhouseini , 
AU  - Saad Mohamed Ali Elgendy , 
TI  - Biological evaluation of Interleukines 2, 12 and taurine combination against human hepatoma cells propagated ex-vivo / 
PY  - 2019///
CY  - Cairo : 
PB  - Tareq Hassan Muhmmad Jorob , 
KW  - Hepatocellular carcinoma (HCC)
KW  - Interleukines 2,12
KW  - Taurine combination
N1  - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology; Issued also as CD
N2  - Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Therefore, it is important to search for agents that have a potential anticancer effect against HCC. The objective of the present study was to investigate the anti-cancer effects of interlekin-2 (IL-2), IL-12 and taurine in human hepatocellular carcinoma cells (Hep-G2). HepG2 cells was obtained from the National Cancer Institute and cultured in RPMI medium. Cells were classified into 6 groups, HepG2 cells without treatment as control group (group A), HepG2 cells treated with IL-2 (group B), HepG2 cells treated with IL-12 (group C), HepG2 cells treated with taurine (group D), HepG2 cells treated with IL-2 and IL-12 (group E) and HepG2 cells treated with IL-2, IL-12 and Taurine (group F). Viability of HepG2 cells was evaluated using MTT assay. Group B, E and F were significantly different from the control group with decreased viability in contrast to group C and D. LDH release assay was used to measure cytotoxicity of the previously mentioned natural agents. There was no significant difference between group D and the control group, while apparent cytotoxicity was observed in group B, C, E and F
ER  -