TY  - BOOK
AU  - Riham Adel Elshiekh
AU  - Dalia A. Almahdy , 
AU  - Essam A. Abdelsattar , 
AU  - Mohamed S. Hifnawy , 
TI  - Assessment of some medicinal plants for treatment of obesity / 
PY  - 2019///
CY  - Cairo : 
PB  - Riham Adel Elshiekh , 
KW  - Solenostemma argel
KW  - Ü-Amylase
KW  - Ü-Glucosidase
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy; Issued also as CD
N2  - The total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants.  An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz:  sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LC{u2013}MS analysis for its content of stemmoside C
ER  -