Walid Mohamed Mohamed Soliman Ghorab <br/><br/>
Synthesis of some novel pyridine derivatives bearing a sulfonamide moiety of expected anticancer activity with studying the augmenting effect of Þ-radiation /  
 تحضير بعض مشتقات البيريدين الجديدة والتي تحمل مجموعة السلفوناميد والمتوقع لها نشاطا كمضادات  للأورام السرطانيه مع دراسة التأثير التحفيزي لأشعة جاما 
Walid Mohamed Mohamed Soliman Ghorab ; Supervised Fatma Abdelfattah Ragab , Helmy Ismail Heiba 
 - Cairo :   Walid Mohamed Mohamed Soliman Ghorab ,   2019 
 - 165 P. :   charts ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry 
<br/><br/> In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action 
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<br/><br/><label>Subjects--Index Terms: </label>Anticancer  Pyridine derivatives  Sulfonamide