TY  - BOOK
AU  - Walid Mohamed Mohamed Soliman Ghorab
AU  - Fatma Abdelfattah Ragab , 
AU  - Helmy Ismail Heiba , 
TI  - Synthesis of some novel pyridine derivatives bearing a sulfonamide moiety of expected anticancer activity with studying the augmenting effect of Þ-radiation / 
PY  - 2019///
CY  - Cairo : 
PB  - Walid Mohamed Mohamed Soliman Ghorab , 
KW  - Anticancer
KW  - Pyridine derivatives
KW  - Sulfonamide
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action
UR  - http://172.23.153.220/th.pdf
ER  -