TY  - BOOK
AU  - Lamiaa Abdelfattah Fathalla Ahmed
AU  - Basma Mostafa Mohammed Elgamal , 
AU  - Naglaa Mostafa Hassan Ahmed , 
AU  - Omnia Kamal Elgebaly , 
TI  - Prevalence and prognostic implication Of BCR/ABL fusion gene expression & JAK2 overexpression In Egyptian acute myeloid leukemia patients / 
PY  - 2019///
CY  - Cairo : 
PB  - Lamiaa Abdelfattah Fathalla Ahmed , 
KW  - BCR/ABL
KW  - JAK2
KW  - Ph+ AML
N1  - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology; Issued also as CD
N2  - Background: Acute myeloid leukemia (AML) is a heterogenous disease with multiple established prognostic factors. JAK2 overexpression in AML was confirmed by many authors with an influence on the overall survival. Philadelphia positive AML (Ph+ AML) is a provisional entity in the recent WHO classification where discrimination from acute blastic crisis on top of chronic myeloid leukemia (CML) is still a challenge. Aims: to study JAK2 gene expression pattern in AML patients and its relation with other established prognostic variables and outcome parameters. Also, to determine the prevalence of the BCR-ABL fusion gene in AML cases with determination of the clinical and laboratory criteria of these cases. Methods: Prospective study on 175 AML patients treated at medical and pediatric oncology departments. Jak2 gene expression was evaluated by real time RT-PCR using taqman primer probe assay and BCR/ABL fusion was tested by conventional RT-PCR. All patients received current standard of care treatment for AML at NCI, Cairo University, Egypt
UR  - http://172.23.153.220/th.pdf
ER  -