TY  - BOOK
AU  - Samar Mohamed Bassam Moaz
AU  - Abeer Mohamed Ali Elsayed , 
AU  - Elmoataz Bellah Ali Elnaggar , 
AU  - Seham Salah Eldin Elhawary , 
TI  - Pharmacognostical investigation of some yucca species (asparagaceae) / 
PY  - 2019///
CY  - Cairo : 
PB  - Samar Mohamed Bassam Moaz , 
KW  - Yucca aloifolia
KW  - Yucca aloifolia variegata
KW  - Yucca filamentosa
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy; Issued also as CD
N2  - Yucca is a genus of woody perennial shrubs and trees, native to Central America northward to southernmost Canada. This genus is highly reputed for its economic importance as a source of fibers and saponins for rope and soap industries, respectively. Yucca aloifolia L., and its variety Yucca aloifolia variegata L., Yucca filamentosa L. and Yucca elephantipes Regel leaves were collected from Orman Botanical Garden, to investigate their biological activities and to carry on phytochemical investigation of the most active species. The plants were first subjected to thorough botanical study and DNA fingerprinting to aid their authentication and identification in any future study. Biological investigation of the total alcoholic extracts of the leaves of the 4 plants, lead to the conclusion of the excellent hepatoprotective effect of the 4 plants using in-vivo CCl4-induced hepatotoxicity model. In-vitro cytotoxicity investigation proved the outstanding cytotoxic activity of Y. aloifolia variegata L.,especially against hepatocellular carcinoma and breast cancer cell lines. However, antimicrobial activity screening showed the lack of activity in both water and alcoholic extracts of the 4 plants.As a result, Y. aloifolia variegata L. was considered the most active and was subjected to further phytochemical investigation. This included preliminary phytochemical screening, determination of total phenolic content, quantitative and qualitative determination of flavonoids and phenolic acids in fraction using HPLC, investigation of lipoid content using GC-MS for both saponifibale and unsaponifiable fractions, and finally LC-MS/MS of the total extract and some fractions. LC-MS/MS was used to for identification of 10 isolated compounds
ER  -