Noha Farid Elshazly <br/><br/>
Effect of curcumin on brain injury induced by intestinal ischemia-reperfusion in mice /  
 تأثير الكركمين في إصابات الدماغ الناتجة عن حبس الدم الموضعي وإعاده الترويه في أمعاء الفئران 
Noha Farid Elshazly ; Supervised Samira Saleh Mostafa , Azza Sayed M. Awad , Nesrine Salah Eldin 
 - Cairo :   Noha Farid Elshazly ,   2019 
 - 126 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> Intestinal ischemia/reperfusion (II/R) induces a systemic inflammatory response and releases harmful substances that may affect the function and integrity of distant organs such as brain, lung, liver, and kidney. Oxidative stress and inflammatory cytokines are among the key mechanisms of brain tissue damage after intestinal ischemia reperfusion. Therefore improving the redox balance, abating the inflammatory cytokines are the most important goals to attenuate damage after intestinal ischemia reperfusion. Curcumin (CUR), the turmeric is the common name for Curcuma longa, exhibit several pharmacologic properties as anti-inflammatory and antioxidant agent and exert neuroprotective effects in a variety of neurodegenerative disorders including Alzheimers disease, Parkinsons disease, and cerebral ischemia by crossing the bloodbrain barrier Moreover, Curcumin is known to play a vital role against oxidative-stress-mediated pathological conditions. , protect biomembranes against peroxidative damage 
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<br/><br/><label>Subjects--Index Terms: </label>Brain injury  Curcumin  Intestinal ischemia/reperfusion (II/R)