TY  - BOOK
AU  - Ghada Fathy Hussein Elmasry
AU  - Enayat Ebrahim Aly , 
AU  - Fadi Mohsen Awadallah , 
AU  - Samir Mohamed Elmoghazy , 
TI  - Design, synthesis and anticancer activity evaluation of new heterocyclic derivatives as PARP inhibitors / 
PY  - 2019///
CY  - Cairo : 
PB  - Ghada Fathy Hussein Elmasry , 
KW  - Olaparib
KW  - PARP-1 inhibitors
KW  - Pyridopyridazinones
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - This work deals with the design and synthesis of some novel pyrido[2,3-d]pyridazinone derivatives; VIIIa-g, IXa,b, Xa-d and XIa-g as PARP-1 inhibitors. Molecular modeling techniques were used to support the design. The twenty newly synthesized compounds were evaluated for their ability to inhibit PARP-1. The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines. Computational ADME study was conducted to ensure that the most active compounds have proper pharmacokinetic and drug-likeness properties
UR  - http://172.23.153.220/th.pdf
ER  -